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6BrCaQ-C10-TPP

CAT: 0804-HY-144831Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144831Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6BrCaQ-C10-TPP is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity in various human cancer cells (IC50=0.008-0.30 μM) . 6BrCaQ-C10-TPP can also induces mitochondrial membrane disturbance[1].
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6brcaq-c10-tpp.html
Solubility
10 mM in DMSO
Smiles
CN1C(C(NC(C2=CC=C(C=C2)OCCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)=CC6=CC(Br)=CC=C61)=O.[Br-]
Molecular Formula
C45H47Br2N2O3P
Molecular Weight
854.65
References & Citations
[1]Mathieu C, et, al. Synthesis and antiproliferative activity of 6BrCaQ-TPP conjugates for targeting the mitochondrial heat shock protein TRAP1. Eur J Med Chem. 2022 Feb 5;229:114052.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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