Gamitrinib TPP

• Description:

  Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.

• UNSPSC:

  12352005

• Target:

  HSP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Gamitrinib_TPP.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C=C1NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]2O)=O)C(NCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=C(C[C@H](C[C@@H]2OC)C)C1=O

• Molecular Formula:

  C52H65N3O8P

• Molecular Weight:

  891.06

• References & Citations:

  [1]Markus D. Siegelin, et al. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest. 2011 Apr 1; 121 (4) : 1349–1360.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HSP90

• Citation 01:

  Cancer Lett. 2025 Aug 9:632:217977.|Exp Ther Med. 2021 Nov;22 (5) :1246.|bioRxiv. 2024 Jan 2.|bioRxiv. 2024 September 03.|Cancer Lett. 2022 Nov 28:549:215915.|Clin Cancer Res. 2022 May 13;28 (10) :2180-2195.|Elife. 2021 Jun 16:10:e63104.|Front Biosci (Landmark Ed) . 2023 Sep 26;28 (9) :227.|J Invest Dermatol. 2025 Feb 18:S0022-202X (25) 00110-1.|Nature. 2020 Mar;579 (7799) :433-437. |Research Square Preprint. 2020 Sep.|Sci Adv. 2025 Oct 24;11 (43) :eadw6064.|SSRN. 2023 Jul 11.

• CAS Number:

  [1131626-46-4]