Products for Research Use Only
RegisterLogin

Gamitrinib TPP hexafluorophosphate

CAT: 0804-HY-102007A-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-102007A-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
CAS Number
1131626-47-5
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Gamitrinib_TPP_hexafluorophosphate.html
Purity
99.68
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCl; heat to 60°C)
Smiles
F[P-](F)(F)(F)(F)F.O=C(C=C1NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]2O)=O)C(NCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=C(C[C@H](C[C@@H]2OC)C)C1=O
Molecular Formula
C52H65F6N3O8P2
Molecular Weight
1036.03
References & Citations
[1]Markus D. Siegelin, et al. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest. 2011 Apr 1; 121 (4) : 1349–1360.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
Citation 01
BioRxiv. 2024 Jan 2.|bioRxiv. 2024 September 03.|Cancer Lett. 2022 Nov 28:549:215915.|Clin Cancer Res. 2022 May 13;28 (10) :2180-2195.|Elife. 2021 Jun 16:10:e63104.|Front Biosci (Landmark Ed) . 2023 Sep 26;28 (9) :227.|J Invest Dermatol. 2025 Feb 18:S0022-202X (25) 00110-1.|Nature. 2020 Mar;579 (7799) :433-437. |Research Square Preprint. 2020 Sep.|Sci Adv. 2025 Oct 24;11 (43) :eadw6064.|SSRN. 2023 Jul 11.|Cancer Lett. 2025 Aug 9:632:217977.|Exp Ther Med. 2021 Nov;22 (5) :1246.

Chemical Information

Gamitrinib TPP hexafluorophosphate
CAS Number1131626-47-5
PubChem CID25232581
IUPAC Name6-[[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-carbamoyloxy-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-19-yl]amino]hexyl-triphenylphosphanium hexafluorophosphate
Molecular FormulaC52H65F6N3O8P2
Molecular Weight1036.0
Topological Polar Surface Area166
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count16
Rotatable Bond Count15
Heavy Atom Count71
Formal Charge0
Complexity1750
SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)/C)OC)OC(=O)N)\C)C)O)OC.F[P-](F)(F)(F)(F)F
InChI
InChI=1S/C52H64N3O8P.F6P/c1-35-31-42-47(54-29-18-7-8-19-30-64(39-22-12-9-13-23-39,40-24-14-10-15-25-40)41-26-16-11-17-27-41)44(56)34-43(49(42)58)55-51(59)36(2)21-20-28-45(61-5)50(63-52(53)60)38(4)33-37(3)48(57)46(32-35)62-6;1-7(2,3,4,5)6/h9-17,20-28,33-35,37,45-46,48,50,57H,7-8,18-19,29-32H2,1-6H3,(H3-,53,54,55,56,58,59,60);/q;-1/p+1/b28-20-,36-21+,38-33+;/t35-,37+,45+,46+,48-,50+;/m1./s1
InChIKey
NFIBTCZSRLMDOD-WLXHSWTPSA-O
Chemical Structure
2D Structure
2D structure of Gamitrinib TPP hexafluorophosphate
CAS: 1131626-47-5
CID: 25232581
Formula: C52H65F6N3O8P2
MW: 1036.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1036.0
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count16
Rotatable Bond Count15
Exact Mass1035.41510901
Monoisotopic Mass1035.41510901
Topological Polar Surface Area166 Ų
Heavy Atom Count71
Formal Charge0
Complexity1750
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count3
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-102007Gamitrinib TPP
HY-159734-01TPP-resveratrol
HY-158189TPP-Ce6
HY-173549CPPA-TPP
HY-P10707Tpp-CAQK
HY-176775TPP-IOA
HY-P3139-01TPP-1
HY-W011734-01Tetramethylfluoroformamidinium (hexafluorophosphate)
HY-W790758-01Tripropylammonium (hexafluorophosphate)
HY-W127673-01Tetramethylammonium (hexafluorophosphate)

Alternative Products

CatalogName
M32933-01Gamitrinib TPP hexafluorophosphate
A21474-25Gamitrinib TPP hexafluorophosphate 25mg
A21474-10Gamitrinib TPP hexafluorophosphate 10mg
A21474-50Gamitrinib TPP hexafluorophosphate 50mg
A21474-5Gamitrinib TPP hexafluorophosphate 5mg
A21474-1Gamitrinib TPP hexafluorophosphate 1mg
GVB62646-01Gamitrinib
MBS387652-01Gamitrinib TPP
CS-O-59734Gamitrinib-d6
A13159-50Gamitrinib TPP 50mg

Popular Products