Simvastatin-d11

Simvastatin-d11

• CAS Number: 1002347-74-1
• UNSPSC Description: Simvastatin-d11 is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1][2].
• Target Antigen: Apoptosis; Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR); Isotope-Labeled Compounds; Mitophagy
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease;Others
• Field of Research: Cancer; Cardiovascular Disease
• Solubility: 10 mM in DMSO
• Smiles: [2H]C([2H])([2H])C([2H])([2H])C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H]3C[C@H](CC(O3)=O)O)C)=C[C@@H](C1)C)=O
• Molecular Weight: 429.63
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35(1):1322-1330.|[3]others
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported