Simvastatin-d11

• Description :

  Simvastatin-d11 is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1][2].

• Product Name Alternative :

  MK 733-d11

• UNSPSC :

  12352005

• Target :

  Apoptosis; Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR) ; Isotope-Labeled Compounds; Mitophagy

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

• Field of Research :

  Cancer; Cardiovascular Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]C([2H])([2H])C([2H])([2H])C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H]3C[C@H](CC(O3)=O)O)C)=C[C@@H](C1)C)=O

• Molecular Formula :

  C25H27D11O5

• Molecular Weight :

  429.63

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35 (1) :1322-1330.|[3]others

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1002347-74-1]