Simvastatin-d11

CAT: 0804-HY-17502S-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17502S-01Size:5 mg
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Description
Simvastatin-d11 is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1][2].
CAS Number
[1002347-74-1]
Product Name Alternative
MK 733-d11
UNSPSC
12352005
Target
Apoptosis; Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR) ; Isotope-Labeled Compounds; Mitophagy
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C([2H])([2H])C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H]3C[C@H](CC(O3)=O)O)C)=C[C@@H](C1)C)=O
Molecular Formula
C25H27D11O5
Molecular Weight
429.63
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35 (1) :1322-1330.|[3]others
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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