Glyburide-d11

CAT: 0804-HY-15206S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15206S-01Size:1 mg
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Description
Glyburide-d11 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) [3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
CAS Number
[1189985-02-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; CFTR; Isotope-Labeled Compounds; Mitochondrial Metabolism; P-glycoprotein; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease
Purity
99.39
Solubility
10 mM in DMSO
Smiles
[2H]C1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])NC(NS(C(C=C2)=CC=C2CCNC(C3=C(C=CC(Cl)=C3)OC)=O)(=O)=O)=O
Molecular Formula
C23H17D11ClN3O5S
Molecular Weight
505.07
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Fernandes MA, et al. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. J Biochem Mol Toxicol. 2004;18 (3) :162-169.|[3]Heo R, et al. The anti-diabetic drug trelagliptin induces vasodilation via activation of Kv channels and SERCA pumps. Life Sci. 2021;283:119868.|[4]Qiu Y, et al. Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade. iScience. 2020;23 (9) :101446.|[5]Golstein PE, et al. P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Arch. 1999;437 (5) :652-660.|[6]Zhou J, et al. Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells. Int J Endocrinol. 2019;2019:1265175.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

CatalogName
RM-G120203-01Glyburide-D11
G8139-05Glyburide-d11 (5-Chloro-N-[2-[4-[[[ (cyclohexylamino) carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide-d11, Adiab-d11, Azuglucon-d11, Bastiverit-d11, Glibenclamide-d11, Glidiabet-d11, Glimidstada-d11)
MBS6087345-01Glyburide-d11 (5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide-d11, Adiab-d11, Azuglucon-d11, Bastiverit-d11, Glibenclamide-d11, Glidiabet-d11, Glimidstada-d11)
MBS3600110-01Glyburide
TRC-C366535-1G3-Chloro Glyburide (Glyburide Impurity)
C08002-01Glyburide (Glibenclamide)
A10433-250Glyburide 250mg
bs-75514C-01Glyburide (USP)
452054Hydroxy Glyburide
RM-G120200-01Glyburide; Glibenclamide

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