Simvastatin acid

• Description:

  Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

• Product Name Alternative:

  Tenivastatin

• UNSPSC:

  12352211

• Target:

  HMG-CoA Reductase (HMGCR) ; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/simvastatin-acid.html

• Purity:

  99.66

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC(C(C)(CC)C)=O)C)C)O)O)O

• Molecular Formula:

  C25H40O6

• Molecular Weight:

  436.58

• References & Citations:

  [1]Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015) . Expert Opin Ther Pat. 2016 Nov;26 (11) :1257-1272.|[2]Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45 (Pt 1) :158-165.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [121009-77-6]