RegisterLogin

Simvastatin-d3

CAT: 0804-HY-17502S1-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17502S1-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Simvastatin-d3 is the deuterium labeled Simvastatin[1]. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[2].
CAS Number
[1002347-61-6]
Product Name Alternative
MK 733-d3
UNSPSC
12352005
Target
Apoptosis; Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR) ; Mitophagy
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cardiovascular Disease
Purity
98.61
Solubility
10 mM in DMSO
Smiles
CCC(C([2H])([2H])[2H])(C)C(O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O
Molecular Formula
C25H35D3O5
Molecular Weight
421.58
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Slater, E.E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-119695AS2Simvastatin acid-d3 (ammonium)
HY-17502-01Simvastatin
HY-119695-01Simvastatin acid
HY-110231Simvastatin-d6
HY-17502S-01Simvastatin-d11
HY-17502R-01Simvastatin (Standard)
HY-1354022'-Ethyl Simvastatin
HY-119695A-01Simvastatin acid (ammonium)
HY-136345A3'-Hydroxy simvastatin
HY-119695SSimvastatin acid-d6

Alternative Products

CatalogName
M15991-01Simvastatin

Popular Products