Simvastatin-d3

• Description :

  Simvastatin-d3 is the deuterium labeled Simvastatin[1]. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[2].

• Product Name Alternative :

  MK 733-d3

• UNSPSC :

  12352005

• Target :

  Apoptosis; Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR) ; Mitophagy

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Autophagy; Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cardiovascular Disease

• Purity :

  98.61

• Solubility :

  10 mM in DMSO

• Smiles :

  CCC(C([2H])([2H])[2H])(C)C(O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O

• Molecular Formula :

  C25H35D3O5

• Molecular Weight :

  421.58

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Slater, E.E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1002347-61-6]