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Simvastatin-d6

CAT: 0804-HY-110231Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-110231Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Simvastatin-d6 (MK 733-d6) is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
CAS Number
1002347-71-8
Product Name Alternative
MK 733-d6
UNSPSC
12352005
Target
Apoptosis; Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR) ; Mitophagy
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease; Cancer
Purity
99.6
Solubility
10 mM in DMSO
Smiles
CCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O[C@@H]1[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H](O3)C[C@H](CC3=O)O)=C[C@H](C)C1)=O
Molecular Formula
C25H32D6O5
Molecular Weight
424.60
References & Citations
[1]Slater E E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82.; Kureishi, Y., et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinas|[2]Kureishi Y, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med. 2000 Sep;6 (9) :1004-10.|[3]Slater EE, et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs. 1988;36 Suppl 3:72-82.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Phase 2

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TRC-S485002-1MGSimvastatin-d6
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TRC-C182402-25MG6’-Carboxy Simvastatin-d6
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sc-4777446-Oxo Simvastatin-d6
sc-2173906'-Carboxy Simvastatin-d6
CS-O-02822Simvastatin-d6 Hydroxy Acid Sodium
sc-4990154α,5-Dihydro Simvastatin-d6
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