Simvastatin-d6
CAT:
804-HY-110231
Size:
500 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Simvastatin-d6
- CAS Number: 1002347-71-8
- UNSPSC Description: Simvastatin-d6 (MK 733-d6) is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
- Target Antigen: Apoptosis; Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR); Mitophagy
- Type: Isotope-Labeled Compounds
- Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease
- Field of Research: Cardiovascular Disease; Cancer
- Solubility: 10 mM in DMSO
- Smiles: CCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O[C@@H]1[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H](O3)C[C@H](CC3=O)O)=C[C@H](C)C1)=O
- Molecular Weight: 424.60
- References & Citations: [1]Slater E E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82.;Kureishi, Y., et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinas|[2]Kureishi Y, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med. 2000 Sep;6(9):1004-10.|[3]Slater EE, et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs. 1988;36 Suppl 3:72-82.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 2