ML-323

CAT: 0804-HY-17543-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17543-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM.
CAS Number
[1572414-83-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ML-323.html
Concentration
10mM
Purity
99.51
Solubility
DMSO : ≥ 49 mg/mL
Smiles
CC1=CN=C(C2=C(C(C)C)C=CC=C2)N=C1NCC3=CC=C(N4N=NC=C4)C=C3
Molecular Formula
C23H24N6
Molecular Weight
384.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Liang Q, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014 Apr;10 (4) :298-304.|[2]Dexheimer TS, et al. Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex. National Center for Biotechnology Information; 2010-2012 Oct 23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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B1317-5.1ML-323
6435/5ML 323
A14030-50ML-323 50mg
A14030-100ML-323 100mg
A14030-1ML-323 1mg
A14030-10ML-323 10mg
A14030-25ML-323 25mg
A14030-5ML-323 5mg
TBI1560-5MGML-323, USP1-UAF1 inhibitor
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