ML-323

• Description:

  ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Deubiquitinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ML-323.html

• Concentration:

  10mM

• Purity:

  99.51

• Solubility:

  DMSO : ≥ 49 mg/mL

• Smiles:

  CC1=CN=C (C2=C (C (C) C) C=CC=C2) N=C1NCC3=CC=C (N4N=NC=C4) C=C3

• Molecular Formula:

  C23H24N6

• Molecular Weight:

  384.48

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Liang Q, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014 Apr;10 (4) :298-304.|[2]Dexheimer TS, et al. Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex. National Center for Biotechnology Information; 2010-2012 Oct 23.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1572414-83-5