(E/Z) -E64FC26

• Description :

  (E/Z) -E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].

• UNSPSC :

  12352005

• Target :

  Apoptosis; PDI

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/e-z-e64fc26.html

• Purity :

  99.80

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC1=CC2=C(/C(C=C2C(F)(F)F)=C/CCCCCCCC)C=C1O

• Molecular Formula :

  C19H23F3O2

• Molecular Weight :

  340.38

• References & Citations :

  [1]Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1.|[2]Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33 (4) :1011-1022.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2285446-67-3]