(E/Z)-E64FC26
CAT:
804-HY-122895A-05
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
(E/Z)-E64FC26
- CAS Number: 2285446-67-3
- UNSPSC Description: (E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].
- Target Antigen: Apoptosis; PDI
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/e-z-e64fc26.html
- Purity: 98.09
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: OC1=CC2=C(/C(C=C2C(F)(F)F)=C/CCCCCCCC)C=C1O
- Molecular Weight: 340.38
- References & Citations: [1]Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1.|[2]Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported