(E/Z) -E64FC26

CAT: 0804-HY-122895A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-122895A-01Size:5 mg
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Description
(E/Z) -E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].
CAS Number
[2285446-67-3]
UNSPSC
12352005
Target
Apoptosis; PDI
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-z-e64fc26.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(/C(C=C2C(F)(F)F)=C/CCCCCCCC)C=C1O
Molecular Formula
C19H23F3O2
Molecular Weight
340.38
References & Citations
[1]Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1.|[2]Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33 (4) :1011-1022.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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