KR-27370

• Description :

  KR-27370 (compound 7f) is an antiviral agent and selective PI4KIIIβ/PI4KIIIα inhibitor (IC50: 3.1 nM/15.8 nM), against hRV, Ke Saatchivirus and other enteroviruses have inhibitory activity[1].br/[1].

• UNSPSC :

  12352005

• Target :

  PI4K

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/kr-27370.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC(OC)=CC(CC(NC2=NC(C)=C(C3=CC=C(OC)C(NS(C4=CC=CC=C4)(=O)=O)=C3)S2)=O)=C1

• Molecular Formula :

  C27H27N3O6S2

• Molecular Weight :

  553.65

• References & Citations :

  [1]G Vishakantegowda A, et al. Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents. RSC Med Chem. 2023 Dec 21;15 (2) :704-719.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PI4KIIIα; PI4KIIIβ