KR-40795

• Description :

  KR-40795 is a potent inhibitor of ATX (autotaxin), with the IC50 of 0.13 μM. KR-40795 plays an important role for liver diseases[1].

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/kr-40795.html

• Smiles :

  O=C1C/C(C(N1C2=CC(Cl)=CC=C2)=O)=C/C3=CC=CC=C3OCC4=CC=C(C=C4)C(OC)=O

• Molecular Formula :

  C26H20ClNO5

• Molecular Weight :

  461.89

• References & Citations :

  [1]Seung Hyeong Lee, et al. Design, synthesis and evaluation of 3- (2- (substituted benzyloxy) benzylidene) pyrrolidine-2,5-dione derivatives for novel ATX inhibitor. Bioorg Med Chem Lett. 2024 Oct 28:114:130006.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported