KR-27425

• Description:

  AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase (AChE) [1].

• UNSPSC:

  12352211

• Target:

  Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/kr-27425.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC (CCCNCCNC (/C=N/O) =O) C

• Molecular Formula:

  C10H21N3O2

• Molecular Weight:

  215.29

• References & Citations:

  [1]Vishakantegowda AG, et al. Discovery of (E) -2- (hydroxyimino) -N- (2 ((4methylpentyl) amino) ethyl) acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129504.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported