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KR-39038

CAT: 0804-HY-143248-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-143248-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KR-39038 is an orally active and potent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 0.02 μM. KR-39038 significantly inhibits angiotensin II-induced cellular hypertrophy through suppression of HDAC5 pathway in neonatal cardiomyocytes. KR-39038 shows profound anti-hypertrophic effects and improved cardiac function. KR-39038 can be used for heart failure research[1].
CAS Number
2770300-35-9
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK) ; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kr-39038.html
Purity
99.68
Solubility
DMSO : 115 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1N=C(C2=C(Cl)C=CC=C2)NC3=CC(NCCCNCCCCNCCCN)=C(C=C13)F
Molecular Formula
C24H32ClFN6O
Molecular Weight
475.00
References & Citations
[1]Lee JH, et al. KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure. Biomol Ther (Seoul) . 2020 Sep 1;28 (5) :482-489.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC5

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