KR-30450

• Description :

  KR-30450 (SKP 450) is a potent K+ATP opener, and a potassium channel activator. KR-30450 exerts more potent cardioprotective effects than Lemakalim (HY-14255) . KR-30450 significantly improves reperfusion cardiac function. KR-30450 significantly attenuates reperfusion contracture and lactate dehydrogenase release[1].

• Product Name Alternative :

  SKP 450

• UNSPSC :

  12352005

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/kr-30450.html

• Smiles :

  O=C1N(C2=C[C@](C)(C3OCCO3)OC4=CC=C([N+]([O-])=O)C=C24)CCC1

• Molecular Formula :

  C17H18N2O6

• Molecular Weight :

  346.33

• References & Citations :

  [1]Jung YS, et al. Cardioprotective effects of KR-30450, a novel K+ (ATP) opener, and its major metabolite KR-30818 on isolated rat hearts. Jpn J Pharmacol. 1998 Jan;76 (1) :65-73.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [172489-10-0]