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EGFR-IN-101

CAT: 0804-HY-161269Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161269Size:1 Each
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Description
EGFR-IN-101 (I-10) is a 2-phenylamino pyrimidine derivative. EGFR-IN-101 is a EGFR inhibitor. The IC50 values for EGFRL858R/T790M/C797S and Ba/F3-EGFRL858R/T790M/C797S are 33.26 and 106.4 nM, respectively. EGFR-IN-101 can be used IN the study of non-small cell lung cancer (NSCLC) [1].
CAS Number
2982583-44-6
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-101.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C2CCN(C3=CC(OC)=C(NC4=NC=CC(N5C=C(CN[C@@H](C)CO)C(C6=CC=CC=C6)=N5)=N4)C=C3C)CC2)CC1
Molecular Formula
C35H47N9O2
Molecular Weight
625.81
References & Citations
[1]Tang C, et al. Design, synthesis and biological evaluation of 2-phenylaminopyrimidine derivatives as EGFR inhibitors. Bioorg Med Chem Lett. 2024 Feb 6;101:129648.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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