CSF1R-IN-20

• CAS Number:

  2935479-57-3

• UNSPSC Description:

  CSF1R-IN-20 (compound 7a) is a CSF-1R Inhibitor with an IC50 value of 467 nM. CSF1R-IN-20 inhibits CSF-1R auto-phosphorylation[1].

• Target Antigen:

  c-Fms

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/csf1r-in-20.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=NOC(C)=C1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4CCN(C)CC4)=C3)=O)=CC=C2C

• Molecular Weight:

  501.50

• References & Citations:

  [1]Jihyun Baek, et al. Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability. Eur J Med Chem. 2024 Feb 20:268:116253.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported