CSF1R-IN-20

CSF1R-IN-20

• CAS Number: 2935479-57-3
• UNSPSC Description: CSF1R-IN-20 (compound 7a) is a CSF-1R Inhibitor with an IC50 value of 467 nM. CSF1R-IN-20 inhibits CSF-1R auto-phosphorylation[1].
• Target Antigen: c-Fms
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/csf1r-in-20.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=NOC(C)=C1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4CCN(C)CC4)=C3)=O)=CC=C2C
• Molecular Weight: 501.50
• References & Citations: [1]Jihyun Baek, et al. Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability. Eur J Med Chem. 2024 Feb 20:268:116253.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported