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CSF1R-IN-3

CAT:
804-HY-139990-06
Size:
100 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
CSF1R-IN-3 - image 1

CSF1R-IN-3

  • CAS Number: 2760584-90-3
  • UNSPSC Description: CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity[1].
  • Target Antigen: c-Fms
  • Type: Reference compound
  • Related Pathways: Protein Tyrosine Kinase/RTK
  • Applications: Cancer-Kinase/protease
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/csf1r-in-3.html
  • Solubility: DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)
  • Smiles: O=C1NC2=CC(NC(NC3=NOC(C(C)(C)C)=C3)=O)=CC=C2/C1=C/C4=C(C)C(NC(CN5CCN(C)CC5)=O)=C(C)N4
  • Molecular Weight: 574.67
  • References & Citations: [1]Lv Q, et al. Discovery of (Z)-1-(3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-3-(isoxazol-3-yl)urea Derivatives as Novel and Orally Highly Effective CSF-1R Inhibitors for Potential Colorectal Cancer Immunotherapy. J Med Chem. 2021;64(23):17184-17208.
  • Shipping Conditions: Room Temperature
  • Clinical Information: No Development Reported