Products for Research Use Only
RegisterLogin

CSF1R-IN-3

CAT: 0804-HY-139990-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-139990-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM) . CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity[1].
CAS Number
2760584-90-3
UNSPSC
12352005
Target
C-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/csf1r-in-3.html
Concentration
10mM
Purity
98.10
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1NC2=CC(NC(NC3=NOC(C(C)(C)C)=C3)=O)=CC=C2/C1=C/C4=C(C)C(NC(CN5CCN(C)CC5)=O)=C(C)N4
Molecular Formula
C30H38N8O4
Molecular Weight
574.67
References & Citations
[1]Lv Q, et al. Discovery of (Z) -1- (3- ((1H-Pyrrol-2-yl) methylene) -2-oxoindolin-6-yl) -3- (isoxazol-3-yl) urea Derivatives as Novel and Orally Highly Effective CSF-1R Inhibitors for Potential Colorectal Cancer Immunotherapy. J Med Chem. 2021;64 (23) :17184-17208.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-157422CSF1R-IN-19
HY-158148CSF1R-IN-23
HY-144040CSF1R-IN-4
HY-147616CSF1R-IN-13
HY-144042CSF1R-IN-6
HY-158363CSF1R-IN-25
HY-144041CSF1R-IN-5
HY-101774-01CSF1R-IN-1
HY-168954CSF1R-IN-26
HY-147611CSF1R-IN-10

Alternative Products

CatalogName
BA8855-5.1CSF1R-IN-3
BZ66244PCMV6-CSF1R-3*FLAG
FP-141CSF1R
BA8854-25CSF1R-IN-1
BA8847-1CSF1R-IN-24
BA8862-10CSF1R-IN-12
GWB-E78B30CSF1R Antibody
T86101-01CSF1R-IN-21
T62318-01CSF1R-IN-9
MBS3603301-01CSF1R-IN-22

Popular Products