CSF1R-IN-23

• UNSPSC Description:

  CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulating factor-1 receptor (CSF1R), with IC50 of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable[1].

• Target Antigen:

  c-Fms

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/csf1r-in-23.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1(NC(C)(CC(C1)C2=CC(C3=CCC(CC3)C)=C(C=C2)NC(C4=NOC(C)=C4)=O)C)C

• Molecular Weight:

  435.60

• References & Citations:

  [1]Baek J, et al., Targeting the CSF-1/CSF-1R Axis: Exploring the Potential of CSF1R Inhibitors in Neurodegenerative Diseases. J Med Chem. 2024 Apr 11;67(7):5699-5720.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2935480-17-2