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CSF1R-IN-23

CAT: 0804-HY-158148Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158148Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulating factor-1 receptor (CSF1R), with IC50 of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable[1].
CAS Number
2935480-17-2
UNSPSC
12352005
Target
C-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/csf1r-in-23.html
Solubility
10 mM in DMSO
Smiles
CC1(NC(C)(CC(C1)C2=CC(C3=CCC(CC3)C)=C(C=C2)NC(C4=NOC(C)=C4)=O)C)C
Molecular Formula
C27H37N3O2
Molecular Weight
435.60
References & Citations
[1]Baek J, et al., Targeting the CSF-1/CSF-1R Axis: Exploring the Potential of CSF1R Inhibitors in Neurodegenerative Diseases. J Med Chem. 2024 Apr 11;67 (7) :5699-5720.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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