CSF1R-IN-23

CSF1R-IN-23

• CAS Number: 2935480-17-2
• UNSPSC Description: CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulating factor-1 receptor (CSF1R), with IC50 of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable[1].
• Target Antigen: c-Fms
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/csf1r-in-23.html
• Solubility: 10 mM in DMSO
• Smiles: CC1(NC(C)(CC(C1)C2=CC(C3=CCC(CC3)C)=C(C=C2)NC(C4=NOC(C)=C4)=O)C)C
• Molecular Weight: 435.60
• References & Citations: [1]Baek J, et al., Targeting the CSF-1/CSF-1R Axis: Exploring the Potential of CSF1R Inhibitors in Neurodegenerative Diseases. J Med Chem. 2024 Apr 11;67(7):5699-5720.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported