S07-2010

• Description :

  S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells[1].

• UNSPSC :

  12352005

• Target :

  Aldose Reductase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/s07-2010.html

• Purity :

  98.35

• Solubility :

  DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1CCCC2=CC(C(CSC3=NC(CCC)=CC(N3)=O)=O)=CC=C2N1

• Molecular Formula :

  C19H21N3O3S

• Molecular Weight :

  371.45

• References & Citations :

  [1]Siyu He, et al. Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance. ACS Med. Chem. Lett. 2022.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1223194-71-5]