GT-2016

• Description:

  GT-2016 is a potent, selective, and brain penetrant histamine H3 receptor antagonist with a Ki of 43.8 nM. GT-2016 displays selectivity against H1 and H2 receptors, and has non-active against histamine methyltransferase[1].

• UNSPSC:

  12352005

• Target:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/gt-2016.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1CCC(C2=CNC=N2)CC1)CCCCC3CCCCC3

• Molecular Formula:

  C19H31N3O

• Molecular Weight:

  317.47

• References & Citations:

  [1]C E Tedford, et al. Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies. J Pharmacol Exp Ther. 1995 Nov;275 (2) :598-604.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  H3 Receptor

• CAS Number:

  [152241-24-2]