WIZ degrader 3

• CAS Number:

  2839637-72-6

• UNSPSC Description:

  WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia[1].

• Target Antigen:

  Histone Acetyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/wiz-degrader-3.html

• Smiles:

  O=C(NC(CC1)=O)N1C2=NOC3=CC=C(C=C23)CN4C[C@@H](N(CC4)C)C

• Molecular Weight:

  357.41

• References & Citations:

  [1]BECKWITH IREJ, et al. Benzisoxazole derivatives and uses thereof. WO2022195355A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported