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IKZF3 degrader 1

CAT: 0804-HY-169077Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169077Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IKZF3 degrader 1 (compound 19a) is a molecular glue degrader of IKZF3 (EC50=0.012 μM) . IKZF3 degrader 1 promotes the binding of IKZF3 to Cereblon (CRBN), leading to the ubiquitination and degradation of IKZF3[1].
UNSPSC
12352005
Target
IKZF Family; Molecular Glues
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ikzf3-degrader-1.html
Smiles
O=C([C@@]1(C2=CC=C(Br)C=C2)C(C3=CC=CC4=C3CN(C(CC5)C(NC5=O)=O)C4=O)=C1)OCC(Cl)(Cl)Cl
Molecular Formula
C25H18BrCl3N2O5
Molecular Weight
612.68
References & Citations
[1]Tracy, et al. "Asymmetric Dirhodium-Catalyzed Modification of Immunomodulatory Imide Drugs and Their Biological Assessment." ACS Medicinal Chemistry Letters (2024) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF3

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