IKZF3 degrader 1

• UNSPSC Description:

  IKZF3 degrader 1 (compound 19a) is a molecular glue degrader of IKZF3 (EC50=0.012 μM). IKZF3 degrader 1 promotes the binding of IKZF3 to Cereblon (CRBN), leading to the ubiquitination and degradation of IKZF3[1].

• Target Antigen:

  IKZF Family; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/ikzf3-degrader-1.html

• Smiles:

  O=C([C@@]1(C2=CC=C(Br)C=C2)C(C3=CC=CC4=C3CN(C(CC5)C(NC5=O)=O)C4=O)=C1)OCC(Cl)(Cl)Cl

• Molecular Weight:

  612.68

• References & Citations:

  [1]Tracy, et al. "Asymmetric Dirhodium-Catalyzed Modification of Immunomodulatory Imide Drugs and Their Biological Assessment." ACS Medicinal Chemistry Letters (2024).

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported