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Ro 08-2750

CAT: 0804-HY-108466-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108466-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA[1]. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM[3].
CAS Number
37854-59-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro-08-2750.html
Purity
98.01
Solubility
DMSO : 4 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=CC1=C(C)C=C2N=C3C(NC(N=C3N(C)C2=C1)=O)=O
Molecular Formula
C13H10N4O3
Molecular Weight
270.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Arkin MR, et al. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov. 2004 Apr;3 (4) :301-17.|[2]Niederhauser O, et al. NGF ligand alters NGF signaling via p75 (NTR) and trkA. J Neurosci Res. 2000 Aug 1;61 (3) :263-72.|[3]Minuesa G, et al. Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 2019 Jun 19;10 (1) :2691.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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