RO 5073012

• Description :

  RO 5073012 is a selective, orally active and brain-penetrant TAAR1 agonist. RO 5073012 shows a Ki of 6 nM for hTAAR1 and EC50 values of 23 and 25 nM for mTAAR1 and rTAAR1. RO 5073012 can be used for the research of neurological disease, such as schizophrenia[1].

• CAS Number :

  [1020814-70-3]

• UNSPSC :

  12352005

• Target :

  Trace Amine-associated Receptor (TAAR)

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Neurological Disease

• Smiles :

  CC(N(C1=CC=C(Cl)C=C1)CC2=CN=CN2)C

• Molecular Formula :

  C13H16ClN3

• Molecular Weight :

  249.74

• References & Citations :

  [1]Galley G, et al. Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012. Bioorg Med Chem Lett. 2012 Aug 15;22 (16) :5244-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TAAR1