CT-08

• Description :

  CT-08 (CT8, Compound 3) is a macrocyclic Sec61 modulator, blocks protein secretion in a signal sequence-dependent manner. CT-08 blocks Sec61-mediated translocation of VCAMss-GLuc into the ER, resulting in a loss of luciferase activity. CT-08 inhibits VCAM expression in transfected cells[1][2].

• UNSPSC :

  12352209

• Target :

  Others

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C(N[C@H](C(N([C@H](C(O[C@@H](C(N[C@H](C(N([C@H](C(N[C@H](C(N1C)=O)CC(C)C)=O)CC(C)C)C)=O)C[C@H](C)CCCC)=O)CC#C)=O)C)C)=O)C[C@H](C)CCCC)[C@@H]1CC2=CC=CC=C2

• Molecular Formula :

  C50H80N6O8

• Molecular Weight :

  893.21

• References & Citations :

  [1]Dustin Mcminn, et al. Preparation of thiazole carboxamides as protein secretion inhibitors for treatment of cancer and inflammation. WO2019046668A1. 2019-03-07. |[2]MacKinnon AL, et al. Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. J Am Chem Soc. 2007 Nov 28;129 (47) :14560-1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [1000770-96-6]