RO-3

• Description:

  RO-3 is a potent, CNS-penetrant, and orally active P2X3 and P2X2/3 antagonist with pIC50s of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. RO-3 shows selectivity for P2X3 and P2X2/3 over all other functional homomultimeric P2X receptors (IC50 >10 μM at P2X1,2,4,5,7) [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H320

• Target:

  P2X Receptor

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ro-3.html

• Purity:

  97.32

• Solubility:

  DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  NC1=NC=C(CC2=CC(OC)=C(OC)C=C2C(C)C)C(N)=N1

• Molecular Formula:

  C16H22N4O2

• Molecular Weight:

  302.37

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]Ford AP, et al. Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol. 2006;147 Suppl 2 (Suppl 2) :S132-S143.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  P2X2 Receptor; P2X3 Receptor

• CAS Number:

  [1026582-88-6]