GR 64349 (TFA)

CAT: 0804-HY-P1278ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P1278ASize:1 Each
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Description
GR 64349 is a potent and highly selective NK2 receptor peptide agonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively[1][2].
UNSPSC
12352209
Target
Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gr-64349-tfa.html
Solubility
10 mM in DMSO
Smiles
CSCC[C@@H](C(N)=O)NC([C@@H](N1C([C@@H](CC1)NC([C@H](C(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@@H](N)CCCCN)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)CC(C)C)=O.O=C(O)C(F)(F)F
Molecular Formula
C44H69F3N10O13S
Molecular Weight
1035.14
References & Citations
[1]Y Chang, et al. Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J Pharmacol Exp Ther. 2000 Jul;294 (1) :147-54.|[2]M J Deal, et al. Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J Med Chem. 1992 Oct 30;35 (22) :4195-204.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NK2R

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