GR-4991W93

• Description :

  GR-4991W93 is an orally active partial agonist against 5HT1B/1D receptor, with pIC50 values of 6.95 and 7.80 against 5HT1B and 5HT1D, respectively. GR-4991W93 demonstrates potent inhibition of electrically evoked plasma extravasation in the guinea pig. GR-4991W93 can be used for migraine research[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Smiles :

  CN(C)[C@H](C1)C[C@@H]1C2=CNC3=CC=C(C[C@@H]4NC(OC4)=O)C=C32

• Molecular Formula :

  C18H23N3O2

• Molecular Weight :

  313.39

• References & Citations :

  [1]Jandu KS, et al. Discovery of 4-[3- (trans-3-dimethylaminocyclobutyl) -1H-indol-5-ylmethyl]- (4S) -oxazolidin-2-one (4991W93), a 5HT (1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem. 2001 Mar 1;44 (5) :681-93.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  5-HT1 Receptor

• CAS Number :

  [171549-56-7]