TCS 1102

CAT: 0804-HY-10900-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10900-01Size:5 mg
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Description
TCS 1102 is a potent, dual orexin receptor antagonist, with Ki values of 0.2 nM and 3 nM for OX2 and OX1 receptors, respectively. TCS 1102 demonstrates excellent blood-brain barrier penetrability and moderate bioavailability in rats[1].
CAS Number
[916141-36-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/TCS-1102.html
Purity
99.73
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H]1N(C(CSC2=NC3=CC=CC=C3N2C)=O)CCC1)NC4=CC=CC=C4C5=CC=CC=C5
Molecular Formula
C27H26N4O2S
Molecular Weight
470.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Bergman JM, et al. Proline bis-amides as potent dual orexin receptor antagonists. Bioorg Med Chem Lett. 2008 Feb 15;18 (4) :1425-30.|[2]Chen X, et al. Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks. Brain Struct Funct. 2013 Aug 18.|[3]Turku A, et al. Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity. PLoS One. 2017 Jun 2;12 (6) :e0178526.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX1 Receptor; OX2 Receptor

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