TCS 401

• Description :

  TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) .

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Phosphatase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/TCS-401.html

• Purity :

  98.0

• Solubility :

  0.1 M NaOH : 6.67 mg/mL (ultrasonic; adjust pH to 9 with NaOH)

• Smiles :

  O=C(C1=C(NC(C(O)=O)=O)SC2=C1CCNC2)O.[H]Cl

• Molecular Formula :

  C10H11ClN2O5S

• Molecular Weight :

  306.72

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Du ZD, et al. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Mol Vis. 2015 May 1;21:523-31.|[2]Ponnusamy M, et al. Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B. Am J Physiol Renal Physiol. 2013 Mar 15;304 (6) :F698-709.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [243966-09-8]