TCS 401

• Description:

  TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) .

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Phosphatase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/TCS-401.html

• Purity:

  98.0

• Solubility:

  0.1 M NaOH : 6.67 mg/mL (ultrasonic; adjust pH to 9 with NaOH)

• Smiles:

  O=C(C1=C(NC(C(O)=O)=O)SC2=C1CCNC2)O.[H]Cl

• Molecular Formula:

  C10H11ClN2O5S

• Molecular Weight:

  306.72

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Du ZD, et al. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Mol Vis. 2015 May 1;21:523-31.|[2]Ponnusamy M, et al. Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B. Am J Physiol Renal Physiol. 2013 Mar 15;304 (6) :F698-709.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [243966-09-8]