TCS 2314

• Description :

  TCS 2314 (compound 3) is orally active and selective very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC50 of 4.4 nM[1].

• UNSPSC :

  12352005

• Target :

  Integrin

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/tcs-2314.html

• Purity :

  99.0

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)CC1CCN(C([C@H]2N(C(CC3=CC=C(NC(NC4=CC=CC=C4C)=O)C=C3)=O)CCOC2)=O)CC1

• Molecular Formula :

  C28H34N4O6

• Molecular Weight :

  522.59

• References & Citations :

  [1]Muro F, et al. Discovery of trans-4-[1-[[2,5-Dichloro-4- (1-methyl-3-indolylcarboxamido) phenyl]acetyl]- (4S) -methoxy- (2S) -pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J Med Chem. 2009 Dec 24;52 (24) :7974-92.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [317353-73-4]