TCS 46b

CAT: 0804-HY-107707-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107707-01Size:5 mg
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Description
TCS 46b (Compound 46b) is a potent, selective and orally active NMDA NR1A/2B receptor antagonist with an IC50 of 5.3 nM[1]. TCS 46b is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[302799-86-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tcs-46b.html
Purity
98.52
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=C(C=C2N1)C#CCN3CCC(CC3)CC4=CC=CC=C4
Molecular Formula
C22H23N3O
Molecular Weight
345.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Wright JL, et al. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1- (heteroarylalkynyl) -4-benzylpiperidines. J Med Chem. 2000 Sep 7;43 (18) :3408-19.|[2]Wright JL, et al. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1- (heteroarylalkynyl) -4-benzylpiperidines. J Med Chem. 2000 Sep 7;43 (18) :3408-19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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