ATL 1102

• Description :

  ATL 1102 (Avicursen) is a novel second-generation antisense oligonucleotide to CD49d mRNA

• CAS Number :

  [350263-41-1]

• Product Name Alternative :

  ISIS-107248; Avicursen

• UNSPSC :

  12352208

• Target :

  Integrin

• Type :

  Oligonucleotides

• Related Pathways :

  Cytoskeleton

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/atl-1102.html

• Solubility :

  10 mM in H2O

• Smiles :

  [ATL1102]

• Molecular Formula :

  C233H327N60O129P19S19

• Molecular Weight :

  7230.14

• References & Citations :

  [1]Duchartre Y, Bachl S, Kim HN, et al. Effects of CD49d-targeted antisense-oligonucleotide on α4 integrin expression and function of acute lymphoblastic leukemia cells: Results of in vitro and in vivo studies. PLoS One. 2017;12 (11) :e0187684. |[2]Limmroth V, Barkhof F, Desem N, Diamond MP, Tachas G; ATL1102 Study Group. CD49d antisense drug ATL1102 reduces disease activity in patients with relapsing-remitting MS [published correction appears in Neurology. 2015 Jan 6;84 (1) :105]. Neurology. 2014;83 (20) :1780-1788.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  Phase 2