MG-1102

CAT: 0931-MF-0120937-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0120937-01Size:10 mg
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AVAILABILITY: InStock
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CAS Number
2567913-75-9
Target
MicroRNA|||Microtubule Associated
Related Pathways
Chromatin/Epigenetic|||Cytoskeletal Signaling
Bioactivity
MG-1102 is a first-in-class dual binder of monomeric tau and pre-miRNA-146a, exhibiting specific inhibition of miRNA146a with IC 50 values of 0.21 mM for double-labeled pre-miRNA146a and 0.36 mM for mono-labeled pre-miRNA146a. It interacts with tau monomers with a K d of 3.21 mM as determined by surface plasmon resonance (SPR), positioning it as a potential multi-target-directed ligand (MTDL) for Alzheimer's disease (AD) [1].
Smiles
C(C=1C(=NNC1)C2=CC3=C(C=C2)C=C(OC)C=C3)N4C(=CC=C4)C5=NC=CS5
Molecular Formula
C22H18N4OS
Molecular Weight
386.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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