MG-1102

• Target :

  MicroRNA|||Microtubule Associated

• Related Pathways :

  Chromatin/Epigenetic|||Cytoskeletal Signaling

• Bioactivity :

  MG-1102 is a first-in-class dual binder of monomeric tau and pre-miRNA-146a, exhibiting specific inhibition of miRNA146a with IC 50 values of 0.21 mM for double-labeled pre-miRNA146a and 0.36 mM for mono-labeled pre-miRNA146a. It interacts with tau monomers with a K d of 3.21 mM as determined by surface plasmon resonance (SPR), positioning it as a potential multi-target-directed ligand (MTDL) for Alzheimer's disease (AD) [1].

• Smiles :

  C(C=1C(=NNC1)C2=CC3=C(C=C2)C=C(OC)C=C3)N4C(=CC=C4)C5=NC=CS5

• Molecular Formula :

  C22H18N4OS

• Molecular Weight :

  386.47

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2567913-75-9