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TCS 359

CAT: 0804-HY-13907-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13907-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent and selective FLT3 inhibitor with an IC50 of 42 nM. TCS 359 inhibits MV4-11 cell proliferation with an IC50 of 340 nM[1].
CAS Number
[301305-73-7]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tcs-359.html
Purity
99.76
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NC(C2=CC=C(OC)C(OC)=C2)=O)SC3=C1CCCC3)N
Molecular Formula
C18H20N2O4S
Molecular Weight
360.43
Precautions
H315, H319, H335
References & Citations
[1]Patch RJ, et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16 (12) :3282-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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