TCS 359

• Description :

  TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent and selective FLT3 inhibitor with an IC50 of 42 nM. TCS 359 inhibits MV4-11 cell proliferation with an IC50 of 340 nM[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  FLT3

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tcs-359.html

• Purity :

  99.76

• Solubility :

  DMSO : 14.29 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(NC(C2=CC=C(OC)C(OC)=C2)=O)SC3=C1CCCC3)N

• Molecular Formula :

  C18H20N2O4S

• Molecular Weight :

  360.43

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Patch RJ, et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16 (12) :3282-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [301305-73-7]