TrxR-IN-5
CAT:
804-HY-147803-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TrxR-IN-5
- UNSPSC Description: TrxR-IN-5 (compound 4f) is a potent TrxR (thioredoxin reductase) inhibitor, with an IC50 of 0.16 μM. TrxR-IN-5 increases the levels of ROS, thus leading to potent antiproliferative effects. TrxR-IN-5 exhibits prominent anticacer and anti-metastasis effects[1].
- Target Antigen: Reactive Oxygen Species
- Type: Reference compound
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/trxr-in-5.html
- Solubility: DMSO : 50 mg/mL (ultrasonic;heat to 60°C)
- Smiles: O=C1C=CCC/C1=C/C2=CC=C(OC3=CC=C(/C=C4CCC=CC\4=O)C=C3)C=C2
- Molecular Weight: 382.45
- References & Citations: [1]Meng C, et al. Efficacy of novel methylenecyclohexenone derivatives as TrxR inhibitors in suppressing the proliferation and metastasis of human cancer cells. Bioorg Chem. 2020 Dec;105:104360.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported