PROTAC ERα Degrader-7

PROTAC ERα Degrader-7

• CAS Number: 3025781-93-2
• UNSPSC Description: PROTAC ERα Degrader-7 (compound i-320) is a potent estrogen receptor alpha(ERα) PROTAC degrader with a DC50 value of 0.000006 µM. PROTAC ERα Degrader-7 comprises a cereblon-binding moiety LBM linked to a ligand ERBM that binds ERα and comprises a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring[1].
• Target Antigen: Estrogen Receptor/ERR; PROTACs
• Type: Reference compound
• Related Pathways: PROTAC;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-erα-degrader-7.html
• Solubility: 10 mM in DMSO
• Smiles: FC1(C[C@H](C2=CC=C(C=C2)C)[C@H](C3=CC=C(N4CCC(CC4)CN5CCN(C6=CC=C(C(N([C@@H]7C(NC(CC7)=O)=O)C8)=O)C8=C6)CC5)C=C3)C9=CC=C(O)C=C91)F
• Molecular Weight: 773.91
• References & Citations: [1]Alexander M. Taylor, et al. Estrogen receptor alpha degraders and use thereof. WO2024006781A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported