PROTAC ERα Degrader-7

• UNSPSC Description:

  PROTAC ERα Degrader-7 (compound i-320) is a potent estrogen receptor alpha(ERα) PROTAC degrader with a DC50 value of 0.000006 µM. PROTAC ERα Degrader-7 comprises a cereblon-binding moiety LBM linked to a ligand ERBM that binds ERα and comprises a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring[1].

• Target Antigen:

  Estrogen Receptor/ERR; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-erα-degrader-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1(C[C@H](C2=CC=C(C=C2)C)[C@H](C3=CC=C(N4CCC(CC4)CN5CCN(C6=CC=C(C(N([C@@H]7C(NC(CC7)=O)=O)C8)=O)C8=C6)CC5)C=C3)C9=CC=C(O)C=C91)F

• Molecular Weight:

  773.91

• References & Citations:

  [1]Alexander M. Taylor, et al. Estrogen receptor alpha degraders and use thereof. WO2024006781A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3025781-93-2