Autophagy inducer 5

Autophagy inducer 5

• UNSPSC Description: Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects[1].
• Target Antigen: Autophagy; JNK; Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Autophagy;Immunology/Inflammation;MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/autophagy-inducer-5.html
• Smiles: O=C([C@]1(C)CC[C@]2(C)CC[C@]3(C)[C@]4(C)C=CC5=C(C)C6=NC7=CC=C(C(NCCN(C)C)=O)C=C7N=C6C=C5C4=CC[C@@]3(C)[C@]2([H])C1)OC
• Molecular Weight: 648.88
• References & Citations: [1]Scaffold Hopping of Pristimerin Provides Derivatives Containing a Privileged Quinoxaline Substructure as Potent Autophagy Inducers in Breast Cancer Cells
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported