Autophagy inducer 2

• UNSPSC Description:

  Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC50 value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer[1].

• Target Antigen:

  Apoptosis; Autophagy

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/autophagy-inducer-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]12[C@@]([C@]3(C(C4=CC5=NC=CN=C5C(C)=C4C=C3)=CC1)C)(CC[C@@]6([C@@]2([H])C[C@@](C)(CC6)NC(N7CCN(C8CCN(CC8)C)CC7)=O)C)C

• Molecular Weight:

  650.94

• References & Citations:

  [1] Feng Y, et al. Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7. Eur J Med Chem. 2022;234:114254.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2684238-37-5