Succinyl phosphonate (trisodium salt)

• UNSPSC Description:

  Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].

• Target Antigen:

  Endogenous Metabolite; Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Field of Research:

  Cancer; Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/succinyl-phosphonate-trisodium-salt.html

• Purity:

  98.0

• Solubility:

  H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(O[Na])CCC(P(O[Na])(O[Na])=O)=O

• Molecular Weight:

  248.01

• References & Citations:

  [1]Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70.|[2]Bunik VI, et al. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget. 2016 May 3;7(18):26400-21.|[3]Zündorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158(2):610-6.|[4]Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61.|[5]Artiukhov AV, et al. Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation. Pharmaceuticals (Basel). 2022 Jan 31;15(2):182.bioRxiv. 2024 Jan 15.|Research Square Preprint. 2022.|Research Square Print. 2022 May.|ACS Chem Biol. 2020 Aug 21;15(8):2041-2047.|Cancer Res. 2019 Jul 1;79(13):3281-3293. |Cell Death Dis. 2021 Oct 25;12(11):999.|Exp Cell Res. 2019 Sep 15;382(2):111483. |Free Radic Biol Med. 2016 Apr 9;96:22-33. |Plant Signal Behav. 2019;14(7):1604015.|Planta. 2018 Oct;248(4):963-979.|Redox Biol. 2023 Jun.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  864167-45-3