ζ-Stat (trisodium)

• Description:

  ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].

• Product Name Alternative:

  NSC37044 (trisodium)

• UNSPSC:

  12352005

• Target:

  Apoptosis; PKC

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Epigenetics; TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ζ-stat-trisodium.html

• Purity:

  97.0

• Solubility:

  H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=S(C1=C2C(O)=CC(S(=O)(O[Na])=O)=CC2=CC(S(=O)(O[Na])=O)=C1)(O[Na])=O

• Molecular Formula:

  C10H5Na3O10S3

• Molecular Weight:

  450.31

• References & Citations:

  [1]Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12 (5) :447-463.|[2]Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PKCζ

• CAS Number:

  [31894-34-5]