ζ-Stat (trisodium)

• Description :

  ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].

• Product Name Alternative :

  NSC37044 (trisodium)

• UNSPSC :

  12352005

• Target :

  Apoptosis; PKC

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Epigenetics; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ζ-stat-trisodium.html

• Purity :

  97.0

• Solubility :

  H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=S(C1=C2C(O)=CC(S(=O)(O[Na])=O)=CC2=CC(S(=O)(O[Na])=O)=C1)(O[Na])=O

• Molecular Formula :

  C10H5Na3O10S3

• Molecular Weight :

  450.31

• References & Citations :

  [1]Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12 (5) :447-463.|[2]Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PKCζ

• CAS Number :

  [31894-34-5]