ζ-Stat (trisodium)

ζ-Stat (trisodium)

• Product Name Alternative: NSC37044 (trisodium)
• CAS Number: 31894-34-5
• UNSPSC Description: ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].
• Target Antigen: Apoptosis; PKC
• Type: Reference compound
• Related Pathways: Apoptosis;Epigenetics;TGF-beta/Smad
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ζ-stat-trisodium.html
• Purity: 97.0
• Solubility: H2O : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=S(C1=C2C(O)=CC(S(=O)(O[Na])=O)=CC2=CC(S(=O)(O[Na])=O)=C1)(O[Na])=O
• Molecular Weight: 450.31
• References & Citations: [1]Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463.|[2]Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported