Succinyl phosphonate

• Target:

  Reactive Oxygen Species|||ROS|||Endogenous Metabolite

• Related Pathways:

  Immunology/Inflammation|||NF-?B|||Metabolism

• Bioactivity:

  Succinyl phosphonate is a selective ?-ketoglutarate dehydrogenase (?-KGDHC) and OGDHC inhibitor that inhibits ?-ketoglutarate oxidative decarboxylation. Succinyl phosphonate trisodium salt inhibits glutamate-induced ROS generation in glutamate-stimulated hippocampal neurons and can be used to study neurodegenerative diseases.

• Smiles:

  O=C(O)CCC(=O)P(=O)(O)O

• Molecular Formula:

  C4H7O6P

• Molecular Weight:

  182.07

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  26647-82-5