NTPO (trisodium)

• UNSPSC Description:

  NTPO trisodium is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO trisodium are abrogated by base excision repair (BER) but not nucleotide excision repair (NER)[1].

• Target Antigen:

  Others

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/ntpo-trisodium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(CN(CP(O)(O[Na])=O)CP(O)(O[Na])=O)(O[Na])O

• Molecular Weight:

  365.00

• References & Citations:

  [1]Choi JY, et al. Non-thermal plasma-induced apoptosis is modulated by ATR- and PARP1-mediated DNA damage responses and circadian clock. Oncotarget. 2016 May 31;7(22):32980-9.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  7611-50-9