Succinyl phosphonate

• UNSPSC Description:

  Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].

• Target Antigen:

  Endogenous Metabolite; Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Succinyl-phosphonate.html

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)CCC(P(O)(O)=O)=O

• Molecular Weight:

  182.07

• References & Citations:

  [1]Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70.|[2]Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutaratedehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61.|[3]Zündorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158(2):610-6.|[4]Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61.ACS Chem Biol. 2020 Aug 21;15(8):2041-2047.|Cancer Res. 2019 Jul 1;79(13):3281-3293. |Cell Death Dis. 2021 Oct 25;12(11):999.|Exp Cell Res. 2019 Sep 15;382(2):111483. |Free Radic Biol Med. 2016 Apr 9;96:22-33. |Plant Signal Behav. 2019;14(7):1604015.|Planta. 2018 Oct;248(4):963-979.|Redox Biol. 2023 Jun.|bioRxiv. 2024 Jan 15.|Research Square Preprint. 2022.|Research Square Print. 2022 May.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  26647-82-5