Succinyl phosphonate

• Description :

  Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H312, H332

• Target :

  Endogenous Metabolite; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Succinyl-phosphonate.html

• Purity :

  98.0

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)CCC(P(O)(O)=O)=O

• Molecular Formula :

  C4H7O6P

• Molecular Weight :

  182.07

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382 (1-2) :167-70.|[2]Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutaratedehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44 (31) :10552-61.|[3]Zündorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158 (2) :610-6.|[4]Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44 (31) :10552-61.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Citation 01 :

  ACS Chem Biol. 2020 Aug 21;15 (8) :2041-2047.|Cancer Res. 2019 Jul 1;79 (13) :3281-3293. |Cell Death Dis. 2021 Oct 25;12 (11) :999.|Exp Cell Res. 2019 Sep 15;382 (2) :111483.|Free Radic Biol Med. 2016 Jul:96:22-33.|Plant Signal Behav. 2019;14 (7) :1604015.|Planta. 2018 Oct;248 (4) :963-979.|Redox Biol. 2023 Jun:62:102669.|bioRxiv. 2024 Jan 15.|Clin Rheumatol. 2025 Nov 20.|Research Square Preprint. 2022.|Research Square Print. 2022 May.

• CAS Number :

  [26647-82-5]