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(E/Z) -Dacinostat

CAT: 0804-HY-116619Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116619Size:1 Each
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Description
(E/Z) -Dacinostat ((E/Z) -NVP-LAQ824) is a histone deacetylase inhibitor that has the ability to induce apoptosis and enhance the activity of fludarabine in killing leukemia cells. (E/Z) -Dacinostat can trigger the production of reactive oxygen species (ROS) and DNA damage, enhance the killing effect of fludarabine on leukemia cells, and induce apoptosis. Its mechanism is related to the regulation of DNA repair processes and intracellular signaling pathways.
CAS Number
591207-53-3
Product Name Alternative
(E/Z) -NVP-LAQ824; (E/Z) -LAQ824
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/e-z-dacinostat.html
Smiles
O=C(/C=C/C1=CC=C(C=C1)CN(CCC2=CC3=C(C=CC=C3)N2)CCO)NO
Molecular Formula
C22H25N3O3
Molecular Weight
379.45
References & Citations
[1]Strategy for enhancing the therapeutic efficacy of histone deacetylase inhibitor dacinostat: the novel paradigm to tackle monotonous cancer chemoresistance
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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