(E/Z) -J147

• Description :

  (E/Z) -J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. (E/Z) -J147 can readily pass the blood brain barrier (BBB) . (E/Z) -J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. (E/Z) -J147 has potential for the treatment of Alzheimer’s disease (AD) [1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Dopamine Transporter; Monoamine Oxidase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/J-147.html

• Purity :

  99.80

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F

• Molecular Formula :

  C18H17F3N2O2

• Molecular Weight :

  350.34

• Precautions :

  H302

• References & Citations :

  [1]Wang M, et al. The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23 (2) :524-7.|[2]Chen Q, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One. 2011;6 (12) :e27865.|[3]Prior M, et al. Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery. Alzheimers Dement. 2016 Jun;12 (6) :678-86.|[4]Prior M, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5 (3) :25.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [1146963-51-0]