(E/Z) -J147

CAT: 0804-HY-13779-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13779-01Size:5 mg
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Description
(E/Z) -J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. (E/Z) -J147 can readily pass the blood brain barrier (BBB) . (E/Z) -J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. (E/Z) -J147 has potential for the treatment of Alzheimer’s disease (AD) [1][2][3].
CAS Number
[1146963-51-0]
UNSPSC
12352005
Hazard Statement
H302
Target
Dopamine Transporter; Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/J-147.html
Purity
99.80
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F
Molecular Formula
C18H17F3N2O2
Molecular Weight
350.34
Precautions
H302
References & Citations
[1]Wang M, et al. The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23 (2) :524-7.|[2]Chen Q, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One. 2011;6 (12) :e27865.|[3]Prior M, et al. Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery. Alzheimers Dement. 2016 Jun;12 (6) :678-86.|[4]Prior M, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5 (3) :25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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