Dacinostat

• Description :

  Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.

• Product Name Alternative :

  NVP-LAQ824; LAQ824

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; HDAC

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Dacinostat.html

• Purity :

  98.45

• Solubility :

  DMSO : ≥ 43 mg/mL

• Smiles :

  O=C(NO)/C=C/C1=CC=C(CN(CCO)CCC2=CNC3=C2C=CC=C3)C=C1

• Molecular Formula :

  C22H25N3O3

• Molecular Weight :

  379.45

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Atadja P, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 2004 Jan 15;64 (2) :689-95.|[2]Cho YS, et al. Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824) . J Med Chem. 2010 Apr 8;53 (7) :2952-63.|[3]Romanski A, et al. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle. 2012 Sep 1;11 (17) :3219-26.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  HDAC; HDAC1

• CAS Number :

  [404951-53-7]