Dacinostat (Standard)

• Description :

  Dacinostat (Standard) is the analytical standard of Dacinostat. This product is intended for research and analytical applications. Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.

• UNSPSC :

  12352100

• Target :

  Autophagy; HDAC; Reference Standards

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others

• Field of Research :

  Cancer

• Smiles :

  O=C(NO)/C=C/C1=CC=C(CN(CCO)CCC2=CNC3=C2C=CC=C3)C=C1

• Molecular Formula :

  C22H25N3O3

• Molecular Weight :

  379.45

• References & Citations :

  [1]Atadja P, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 2004 Jan 15;64 (2) :689-95.|[2]Cho YS, et al. Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824) . J Med Chem. 2010 Apr 8;53 (7) :2952-63.|[3]Romanski A, et al. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle. 2012 Sep 1;11 (17) :3219-26.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [404951-53-7]